专家队伍

颜富

湖南师范大学教授

E-mail: fuyan@hunnu.edu.cn

通讯地址：湖南省长沙市岳麓区湖南师范大学生命科学学院，410081

2017年博士毕业于德国萨尔大学/萨尔州亥姆霍兹药物研究所，师从Rolf Müller教授，获自然科学博士学位。2017-2019年在萨尔州亥姆霍兹药物研究所从事博士后研究。2019-2025年任山东大学微生物改造技术全国重点实验室教授，博士生导师；2025年加入湖南师范大学生命科学学院。主要从事合成生物学使能技术开发、微生物活性天然产物的发掘与生物合成机制研究等。在Angewandte Chemie International Edition，Chemical Science，Natural Product Reports，Organic Letters和ACS Chemical Biology等国际权威刊物上发表论文20余篇，申请和授权国家发明专利5项，主持和参与国家级项目4项、省部级项目2项。

主持和参与的科研项目

1. 国家自然科学基金青年基金（82003639），厌氧梭菌活性天然产物的发现及生物合成机制研究，2021-2023，主持

2. 山东省自然科学基金重大基础研究项目，ZR2023ZD29，微生物活性多肽的定向挖掘与合成生物学改造，2024-2026，主持

3. 山东省“泰山学者”青年专家计划，tsqn201909049，2020-2024，主持

4. 国家重点研发计划“合成生物学”重点专项子课题（2019YFA0904003），基因组重编程实现噬菌体精准控制，2020-2024，主持子课题

5. 国家重点研发计划“绿色生物制造”重点专项青年科学家项目，2021YFC2102500，工业微生物基因组大片段DNA的设计原理与操纵方法，2021-2024，负责子任务

6. 国家基金委国际(地区)合作与交流项目，32161133013，微生物次级代谢混合能力挖掘：细菌杂合萜烯类天然产物生物合成，2022-2024，参与

近几年主要论文：

Zong-jie Wang, Haibo Zhou, Youming Zhang, Fu Yan,* Liujie Huo,* Xiaotong Wang*. RECC: A Red/ET–CRISPR/Cas9-based system enabling genome mining of marine Pseudoalteromonas for novel natural products. Synthetic and Systems Biotechnology, 2026, 12: 342–351

Quan Dai, Yiqiao Li, Shuzhe Lv, Shuang Zhao, Liyuan Han, Jiaxin Xu, Hui Shuai, Youming Zhang,* Fu Yan*. Genome Mining and Heterologous Reconstitution of a PKS-NRPS Gene Cluster from Aspergillus flavipes LY1-5 Affords Structurally Novel Tetronates. Journal of Fungi, 2026, 12(1): 28

Yuan Gu,^# Zong-Jie Wang,^# Huimei Wang,^# Anqi Su, Quan Dai, Youming Zhang, Liujie Huo*, Fu Yan*. Biosynthetic Investigations of Ulbactins Unveil Two Novel Thiazolinyl Imine Reductases Crucial for the Generation of Siderophore Activity. Journal of Agricultural and Food Chemistry, 2025, 73(14): 8352−8366.

Liyuan Han, Jiaxin Xu, Yuan Gu, Ruiying Feng, Shuo Liu, Qiujie Lu, Shuzhe Lv, Youming Zhang*, Fu Yan*. Teichoic acid biosynthesis enhances conjugation efficiency in Streptomyces: A key to unlocking DNA delivery into industrially relevant strains. International Journal of Biological Macromolecules, 2025, 307(3):142248.

Ruiying Feng,^# Quan Dai,^# Meina Ma,^# Shuang Zhao, Zongjie Wang, Huimei Wang, Youming Zhang*, Liujie Huo*, Fu Yan*. Discovery of Ureido-Containing Alteropeptilides and Intramolecular Cyclized Alteramides in Pseudoalteromonas flavipulchra S16 by Promoter Engineering of Cryptic Biosynthetic Gene Clusters. Journal of Natural Products, 2024, 87, 2801-2809.

Xiaomei Cong, Shuang Zhao, Qing Zhang, Shuo Liu, Youming Zhang*, Fu Yan*. Isolation, Characterization, and Genome Engineering of a Lytic Pseudomonas aeruginosa Phage. Microorganisms, 2024, 12(11), 2346.

Shuang Zhao,^# Ruiying Feng,^# Yuan Gu,^# Liyuan Han, Xiaomei Cong, Yang Liu, Shuo Liu, Qiyao Shen, Liujie Huo, Fu Yan*. Heterologous expression facilitates the discovery and characterization of marine microbial natural products. Engineering Microbiology, 2024, 4(2): 100137

Yang Liu,^# Haibo Zhou,^# Shuang Zhao, Xingkun Hao, Guangzhi Dai, Lin Zhong, Xiangmei Ren, Haiyan Sui, Youming Zhang,* Fu Yan,* Xiaoying Bian*. Biosynthesis of trans-AT PKS-derived Shuangdaolides featuring a trans-acting enzyme for online epoxidation. ACS Chemical Biology, 2023, 18(12): 2474–2484

Renzong Liu, Yi Sun, Meina Ma, Liyuan Han, Sheng Gao, Youming Zhang, Fu Yan*. Aurantimonas marianensis sp. nov., isolated from deep-sea sediment of the Mariana Trench. International Journal of Systematic and Evolutionary Microbiology, 2023, 73(4): 005816

Guannan Zhong,^# Zong-Jie Wang,^# Fu Yan, Youming Zhang, Liujie Huo*. Recent advances in discovery, bioengineering, and bioactivity-evaluation of ribosomally synthesized and post-translationally modified peptides. ACS Bio & Med Chem Au, 2023, 3 (1): 1-31

Songya Zhang,^# Yunliang Chen,^# Jing Zhu, Qiujie Lu, Max J. Cryle,* Youming Zhang*, Fu Yan*. Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces. Natural Product Reports, 2023, 40, 557-594

Zhiguo Liu, Yoko Yashiroda,  Peng Sun,  Hai Ma,  Yanan Wang, Li Li, Fu Yan*, Yi Sun*. Argenteolides A and B, glycosylated polyketide–peptide hybrid macrolides from an actinomycete Streptomyces argenteolus. Organic Letters, 2023, 25(4), 571−575

Fu Yan, Rolf Müller*. Class I methyltransferase VioH catalyzes unusual SAM cyclization leading to 4-methylazetidinecarboxylic acid formation in vioprolide biosynthesis. ACS Chemical Biology, 2019, 14(1), 99–105

David Auerbach,^# Fu Yan,^# Youming Zhang, Rolf Müller*. Characterization of an unusual glycerate esterification process in vioprolide biosynthesis. ACS Chemical Biology, 2018, 13(11), 3123–3130

Fu Yan,^# Christian Burgard,^# Alexander Popoff, Nestor Zaburannyi, Gregor Zipf, Josef Maier, Hubert S. Bernauer, Silke C. Wenzel, Rolf Müller*. Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production. Chemical Science, 2018, 9, 7510-7519

Fu Yan,^# David Auerbach,^# Yi Chai, Lena Keller, Qiang Tu, Stephan Hüttel, Ameli Glemser, Hanusch A. Grab, Thorsten Bach, Youming Zhang,* Rolf Müller*. Biosynthesis and heterologous production of vioprolides: rational biosynthetic engineering and unprecedented 4-methylazetidinecarboxylic acid formation. Angewandt Chemie International Edition, 2018, 57(28):8754-8759