
胡益波,博士,副教授,硕导,毕业于山东大学微生物国家重点实验室,从事丝状真菌高效蛋白表达系统的构建,利用合成生物学方法对表达宿主进行优化和表达元件的挖掘,同时进行鱼类抗菌肽等高附加值蛋白的异源性表达及优化。
项目:
胡益波 2023JJ30395 湖南省自然科学基金面上基金: 多肽高效生物合成的新型青霉细胞工厂的设计与构建;(2022-2024)。
胡益波 kq2208169 长沙市自然科学基金面上项目:适于多肽表达的丝状真菌高效表达系统构建研究;(2022-2024)。
胡益波 21B0047 教育厅省优秀青年基金: 青霉蛋白分泌机器零件优化研究;(2021-2023)。
文章:
1.Guo D, Zhao S, Chen J, Han S, Li Y, Chen Y, Hu S, Hu Yibo*. Modification of essential factors mediating post-translational processing for high-quality protein expression in Penicillium. Eng Microbiol. 2025; 5:100194.
2.Guo D, Zhao S, Chen J, Han S, Li Y, Chen Y, Hu S, Hu Yibo*. Heterochromatin protein activates the amylase expression pathway and its application to recombinant protein expression in Penicillium oxalicum. Curr Microbiol. 2025;82(2):75. (三区)
3.Zhao S, Xiang B, Yang L, Chen J, Zhu C, Chen Y, Cui J, Hu S, Hu Yibo*. Genetic modifications of critical regulators provide new insights into regulation modes of raw-starch-digesting enzyme expression in Penicillium. Biotechnol Biofuels Bioprod(原Biotechnol Biofuels)2022;15(1):62. (一区)
4.Zhang Z, Xiang B, Zhao S, Yang L, Chen Y, Hu Yibo*, Hu S. Construction of a novel filamentous fungal protein expression system based on redesigning of regulatory elements. Appl Microbiol Biotechnol;2022;106(2):647-661.(二区)
5.Changyu Pi, Zhe Zhang, Boyu Xiang, Hongwei Tian, Qinzhen Liao, Yu Chen, Liqiu Xia, Shengbiao Hu,Yibo Hu*(2020); Constructing a novel expression system by specific activation of amylase expression pathway in Penicillium. Microbial Cell Factories 19(1):155. doi: 10.1186/s12934-020-01410-4.(二区)
6.Yibo Hu , Yuqi Q , Guodong L (2018). Collection and Curation of Transcriptional Regulatory Interactions in Aspergillus nidulans and Neurospora crassa Reveal Structural and Evolutionary Features of the Regulatory Networks[J]. Frontiers in Microbiology, 9:27(二区)
7.Yibo Hu, H,Xue, G,Liu, X,Song, Y,Qu (2015) Efficient production and evaluation of lignocellulolytic enzymes using a constitutive protein expressionsystem in Penicillium oxalicum, 1-11. doi: 10.1007/s10295-015-1607-8. Journal of Industrial Microbiology & Biotechnology(三区)
8.Yibo Hu, G,Liu, Z,Li, Y ,Qin,Y ,Qu, X,Song (2013) G protein-cAMP signaling pathway mediated by PGA3 plays opposite roles in regulating the expressionsof amylases and cellulases in Penicillium decumbens. 58-59:62-70. Fungal Genetics and Biology (二区)
发明专利:
1.一种提高草酸青霉淀粉酶表达效率的方法
2.一种提高淀粉酶活性的草酸青霉及其构建方法
邮箱
huyibo@hunnu.edu.cn
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